Two observations suggest that chemotaxis may play a role in

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side effects of steroids The studies of cation distribution were largely inconclusive, as though modified cation movements were clearly seen in various conditions known to inhibit NaKMgATPase activity, it was not possible to identify firmly the position of such an enzyme or indeed that it was the sole site of action. Measurements of oxygen uptake failed to reveal any portion of oxidative metabolism which could be ascribed to metabolic activity linked to NaKMgATPase activity. After a variety of isolation techniques had failed to produce a fraction of skeletal muscle containing a clearly demonstrable NaKMgATPase, a procedure involving exposure of the muscle homogenate to 2 M NaI was successful in separating a membrane fraction exhibiting NaKMgATPase activity from rat diaphragm and hind limb muscle. side effects of steroids

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